Extreme dynamics in a biomolecular condensate.

ABSTRACT: Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular condensates^1-4. The functions of condensates span many length scales: they modulate interactions and chemical reactions at the molecular scale⁵, organize biochemical processes at the mesoscale⁶ and compartmentalize cells⁴. Understanding the underlying mechanisms of these processes will require detailed knowledge of the rich dynamics across these scales⁷. The mesoscopic dynamics of biomolecular condensates have been extensively characterized⁸, but their behaviour at the molecular scale has remained more elusive. Here, as an example of biomolecular phase separation, we study complex coacervates of two highly and oppositely charged disor

SUBMITTER: Galvanetto N 

PROVIDER: S-EPMC11508043 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature