HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983-2015.

ABSTRACT:

Introduction

HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB).

Methods

We included people living with HIV from 25 European cohorts 1983-2015. Individuals <16 years or with previous TB were excluded. Person-time was calculated from enrolment (baseline) to the date of TB diagnosis or last follow-up information. We used adjusted Poisson regression and general additive regression models.

Results

We included 272,548 people with a median follow-up of 5.9 years (interquartile range [IQR] 2.3-10.9). At baseline, the median CD4 cell count was 355 cells/μL (IQR 193-540) and the median HIV-RNA level 22,000 copies/mL (I

SUBMITTER: Atkinson A 

PROVIDER: S-EPMC11508122 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature