Molecular Mechanism of Radioresponsiveness in Colorectal Cancer: A Systematic Review.

ABSTRACT: Background/Objectives: Colorectal cancer (CRC) is the third most diagnosed cancer globally. Radiotherapy is a common treatment strategy for patients but factors such as gene expressions and molecular mechanism effects may affect tumor radioresponse. The aim of this review is to systematically identify genes suggested to have molecular mechanism effects on the radioresponsiveness of CRC patients. Methods: By following the PRISMA guidelines, a comprehensive literature search was conducted on Pubmed, EMBASE and Cochrane Library. After exclusion and inclusion criteria sorting and critical appraisal for study quality, data were extracted from seven studies. A gene set analysis was conducted on reported genes. Results: From the seven studies, 56 genes were found to have an e

SUBMITTER: Lau MYH 

PROVIDER: S-EPMC11508137 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature