Higher Body Mass Index Is Associated With Decreased Treatment Response to Topical Steroids in Eosinophilic Esophagitis.

ABSTRACT:

Background & aims

Understanding which eosinophilic esophagitis (EoE) patients will respond to treatment with topical corticosteroids (tCS) remains challenging, and it is unknown whether obesity impacts treatment response. This study aimed to determine whether treatment outcomes to tCS in EoE patients vary by body mass index (BMI).

Methods

This retrospective cohort study of the University of North Carolina EoE Clinicopathologic database assessed subjects age 14 years or older with a new diagnosis of EoE. Their BMI was calculated and histologic, symptom, and endoscopic responses were recorded after tCS treatment. The treatment response of obese (BMI, ≥30 kg/m²) and nonobese EoE status was compared using bivariate and multivariate analyses.

Results

We identifi

SUBMITTER: Ketchem CJ 

PROVIDER: S-EPMC11508185 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature