Ribosome Structural Changes Dynamically Affect Ribosome Function.

ABSTRACT: Ribosomes were known to be multicomponent complexes as early as the 1960s. Nonetheless, the prevailing view for decades considered active ribosomes to be a monolithic population, in which all ribosomes are identical in composition and function. This implied that ribosomes themselves did not actively contribute to the regulation of protein synthesis. In this perspective, I review evidence for a different model, based on results showing that ribosomes can harbor different types of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins) and, furthermore, need not contain a complete set of r-proteins. I also summarize recent results favoring the notion that such distinct types of ribosomes have different affinities for specific messenger RNAs and may execute the translation process differentl

SUBMITTER: Lindahl L 

PROVIDER: S-EPMC11508205 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature