<i>Toxoplasma gondii</i> ROP5 Enhances Type I IFN Responses by Promoting Ubiquitination of STING.

ABSTRACT: Toxoplasma gondii is a widely spread opportunistic pathogen that can infect nearly all warm-blooded vertebrates and cause serious toxoplasmosis in immunosuppressed animals and patients. However, the relationship between the host's innate immune system and effector proteins is poorly understood, particularly with regard to how effectors antagonize cGAS-STING signaling during T. gondii infection. In this study, the ROP5 from the PRU strain of T. gondii was found to promote cGAS-STING-mediated immune responses. Mechanistically, ROP5 interacted with STING through predicted domain 2 and modulated cGAS-STING signaling in a predicted domain 3-dependent manner. Additionally, ROP5 strengthened cGAS-STING signaling by enhancing the K63-linked ubiquitination of STING. Consistentl

SUBMITTER: Jin QW 

PROVIDER: S-EPMC11508707 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature