Population Heterogeneity and Selection of Coronary Artery Disease Polygenic Scores.

ABSTRACT:

Background/objectives

The identification of coronary artery disease (CAD) high-risk individuals is a major clinical need for timely diagnosis and intervention. Many different polygenic scores (PGSs) for CAD risk are available today to estimate the genetic risk. It is necessary to carefully choose the score to use, in particular for studies on populations, which are not adequately represented in the large datasets of European biobanks, such as the Italian one. This work aimed to analyze which PGS had the best performance within the Italian population.

Methods

We used two Italian independent cohorts: the EPICOR case-control study (576 individuals) and the Atherosclerosis, Thrombosis, and Vascular Biology (ATVB) Italian study (3359 individuals). We evaluated 266 PGS for cardiov

SUBMITTER: Debernardi C 

PROVIDER: S-EPMC11508882 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature