Trophoblast-specific overexpression of adiponectin receptor 2 causes fetal growth restriction in pregnant mice.

ABSTRACT: Maternal obesity in pregnancy is strongly associated with complications such as fetal overgrowth and infants of obese mothers have an increased risk to develop obesity, diabetes, and cardiovascular disease later in life. However, the underlying mechanisms are not well established. Circulating levels of adiponectin are low in obese pregnant women and maternal circulating adiponectin is negatively associated with birth weight. We have reported that normalizing maternal adiponectin in obese pregnant mice prevents placental dysfunction, fetal overgrowth, and programming of offspring cardio-metabolic disease. However, the mechanistic link between maternal adiponectin, placental function, and fetal growth remains to be established. We hypothesized that trophoblast-specific overexpression of the

SUBMITTER: Dumolt JH 

PROVIDER: S-EPMC11508969 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature