Two Forms of Thick Filament in the Flight Muscle of <i>Drosophila melanogaster</i>.

ABSTRACT: Invertebrate striated muscle myosin filaments are highly variable in structure. The best characterized myosin filaments are those found in insect indirect flight muscle (IFM) in which the flight-powering muscles are not attached directly to the wings. Four insect orders, Hemiptera, Diptera, Hymenoptera, and Coleoptera, have evolved IFM. IFM thick filaments from the first three orders have highly similar myosin arrangements but differ significantly among their non-myosin proteins. The cryo-electron microscopy of isolated IFM myosin filaments from the Dipteran Drosophila melanogaster described here revealed the coexistence of two distinct filament types, one presenting a tubular backbone like in previous work and the other a solid backbone. Inside an annulus of myosin tails, tubular f

SUBMITTER: Rastegarpouyani H 

PROVIDER: S-EPMC11509062 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature