Discovery of Anti-Inflammatory Alkaloids from Sponge <i>Stylissa massa</i> Suggests New Biosynthetic Pathways for Pyrrole-Imidazole Alkaloids.

ABSTRACT: Pyrrole-imidazole alkaloids (PIAs) are a class of marine sponge derived natural products which have complex carbon frameworks and broad bioactivities. In this study, four new alkaloids, stylimassalins A-B (1-2), 3, and 5, together with two known compounds (4 and 6), were isolated from Stylissa massa. Compounds 2, 4, and 6 are the C-2 brominated analogues of 1, 3, and 5, respectively. Their structures display three different scaffolds, of which scaffold 1 (compounds 1,2) is new. A new biosynthetic pathway from oroidin, through spongiacidin, to latonduine and scaffold 1 was proposed by our group, in which the C12-N13-cleavaged compounds of spongiacidin (scaffold 2), dubbed seco-spongiacid

SUBMITTER: Liu X 

PROVIDER: S-EPMC11509139 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature