Assessing the Effects of Surgical Irrigation Solutions on Human Neutrophil Interactions with Nascent <i>Staphylococcus aureus</i> Biofilms.

ABSTRACT: Staphylococcus aureus (S. aureus) is the leading cause of surgical site infections (SSIs) and is capable of biofilm growth on implanted foreign devices. The use of surgical irrigation solutions has become a common strategy to combat bacterial contamination events that occur during surgery. Despite their antimicrobial activity, SSI rates remain consistent, suggesting that low-level contamination persists. In these cases, circulating neutrophils must traffic from the blood to contamination sites to aid in bacterial clearance. The influence of irrigation solutions on neutrophils' ability to engage with bacteria has not been explored. The effects of three commonly used irrigation solutions: Xperience (sodium lauryl sulfate), Irrisept (chlorhexidine gluconate), and Betadine^®<

SUBMITTER: Gaur G 

PROVIDER: S-EPMC11509154 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature