Cohesin <i>RAD21</i> Gene Promoter Methylation in Patients with Acute Myeloid Leukemia.

ABSTRACT:

Background

Aberrant gene promoter methylation is one of the hallmarks of Acute Myeloid Leukemia (AML). RAD21 is an important gene, implicated in sister chromatids cohesion, DNA repair, the regulation of gene transcription, apoptosis and hematopoiesis.

Methods

In this study, we investigate the possible implication of RAD21 promoter methylation in AML pathogenesis using a cohort of AML patients and a cohort of healthy individuals.

Results

RAD21 promoter methylation was found in 24% of patients and in none of the controls (p = 0.023), indicating a possible contribution to AML development. Interestingly, a statistically higher frequency of RAD21 methylation was observed in patients with trisomy 8 (9/21, 42.9%, p = 0.021), while no

SUBMITTER: Manola KN 

PROVIDER: S-EPMC11509327 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature