Adrenal Insufficiency in Patients with Beta Thalassemia: A Meta-Analysis.

ABSTRACT: Background and Objectives: Adrenal insufficiency (AI) can be a significant concern in patients with transfusion-dependent homozygous beta thalassemia (bThal) due to the chronic disease burden and frequent blood transfusions that these patients require. The prevalence of AI in this population remains unclear, with studies often lacking control groups for comparison. This meta-analysis aimed to estimate the proportion of patients with transfusion-dependent bThal who exhibit evidence of AI. Materials and Methods: A systematic review following PRISMA guidelines identified 19 studies for analysis. Results: Despite the variability in the diagnostic methods used to ascertain AI, the meta-analysis revealed that approximately one-third of patients had evidence of AI, with the p

SUBMITTER: Savvidis C 

PROVIDER: S-EPMC11509364 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature