Isolation of Virulent <i>Leptospira</i> Serogroup Australis Field Strains from Symptomatic Dogs for Canine Leptospiral Vaccine Development.

ABSTRACT: Leptospirosis is a widespread zoonosis caused by spirochaetes belonging to the pathogenic species of Leptospira, which are classified into more than 25 serogroups and 250 serovars. Vaccination can prevent the disease in dogs but offers incomplete efficacy because of a lack of cross-protection between serogroups. The aim of this study was to validate a robust recruitment and sampling process, with the objectives of isolating and typing circulating Leptospira pathogenic strains and then selecting those of proven virulence and pathogenicity for vaccine development. Blood and urine samples from dogs with clinical syndromes compatible with acute leptospirosis were sterilely collected and transported to a reference laboratory for a micro-agglutination test (MAT), PCR, and bacterial

SUBMITTER: Bergamo P 

PROVIDER: S-EPMC11509459 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature