Antioxidative and Anti-Atopic Dermatitis Effects of Peptides Derived from Hydrolyzed <i>Sebastes schlegelii</i> Tail By-Products.

ABSTRACT: Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with significant morbidity, including pruritus, recurrent skin lesions, and immune dysregulation. This study aimed to investigate the antioxidative and anti-AD effects of peptides derived from hydrolyzed Sebastes schlegelii (Korea rockfish) tail by-products. Hydrolysates were prepared using various enzymes, including Alcalase, Flavourzyme, Neutrase, and Protamex. Among them, Protamex hydrolysates demonstrated the highest ABTS radical scavenging activity with an RC₅₀ value of 69.69 ± 0.41 µg/mL. Peptides were further isolated from the Protamex hydrolysate using dialysis, fast protein liquid chromatography (FPLC), and high-performance liquid chromatography (HPLC). The most active peptide, STPO-B-II, e

SUBMITTER: Lee SG 

PROVIDER: S-EPMC11509535 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature