Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <i>Vibrio cholerae</i> from Seventh Pandemic.

ABSTRACT: CTXΦ is a lysogenic filamentous phage that carries the genes encoding cholera toxin (ctxAB), the main virulence factor of Vibrio cholerae. The toxigenic conversion of environmental V. cholerae strains through CTXΦ lysogenic infection is crucial for the emergence of new pathogenic clones. A special allelic form of CTXΦ, called pre-CTXΦ, is a precursor of CTXΦ and without ctxAB. Different members of the pre-CTXΦ and CTXΦ families are distinguished by the sequence of the transcriptional repressor-coding gene rstR. Multiple rstR alleles can coexist within a single strain, demonstrating the diverse structure and complex genomic integration patterns of CTXΦ/pre-CTXΦ prophage on the chromosome. Exploration of the diversity and co-integration patterns of C

SUBMITTER: Li X 

PROVIDER: S-EPMC11509585 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature