New Fusarochromanone Derivatives from the Marine Fungus Fusarium equiseti UBOCC-A-117302.

ABSTRACT: Two new fusarochromanone derivatives, deacetylfusarochromene (1) and deacetamidofusarochrom-2',3-diene (2), along with the previously reported metabolites fusarochromanone TDP-2 (3), fusarochromene (4), 2,2-dimethyl-5-amino-6-(2'E-ene-4'-hydroxylbutyryl)-4-chromone (5), fusarochromanone (6), (-)-chrysogine (7), and equisetin (8), were isolated from the marine fungus Fusarium equiseti UBOCC-A-117302. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Among them, 2 and 5 showed inhibition of three protein kinases with IC₅₀ values ranging from 1.42 to 25.48 μM. Cytotoxicity and antimicrobial acti

SUBMITTER: Pham GN 

PROVIDER: S-EPMC11509758 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature