<i>Francisella novicida</i>-Containing Vacuole within <i>Dictyostelium discoideum</i>: Isolation and Proteomic Characterization.

ABSTRACT: Francisella is a highly infectious gram-negative bacterium that causes tularemia in humans and animals. It can survive and multiply in a variety of cells, including macrophages, dendritic cells, amoebae, and arthropod-derived cells. However, the intracellular life cycle of a bacterium varies depending on the cell type. Shortly after the infection of mammalian cells, the bacterium escapes the phagosome into the cytosol, where it replicates. In contrast, in the amoebae Acanthamoeba castellanii and Hartmannella vermiformis, the bacterium replicates within the membrane-bound vacuole. In recent years, the amoeba Dictyostelium discoideum has emerged as a powerful model to study the intracellular cycle and virulence of many pathogenic bacteria. In this study, we used <

SUBMITTER: Marecic V 

PROVIDER: S-EPMC11509842 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature