Immunoinformatics Design of a Multiepitope Vaccine (MEV) Targeting <i>Streptococcus mutans</i>: A Novel Computational Approach.

ABSTRACT: Dental caries, a persistent oral health challenge primarily linked to Streptococcus mutans, extends its implications beyond dental decay, affecting over 4 billion individuals globally. Despite its historical association with childhood, dental caries often persists into adulthood with prevalence rates ranging from 60 to 90% in children and 26 to 85% in adults. Currently, there is a dearth of multiepitope vaccines (MEVs) specifically designed to combat S. mutans. To address this gap, we employed an immunoinformatics approach for MEV design, identifying five promising vaccine candidates (PBP2X, PBP2b, MurG, ATP-F, and AGPAT) based on antigenicity and conservation using several tools including CELLO v.2.5, Vaxign, v2.0, ANTIGENpro, and AllerTop v2.0 tools. Subsequent identificati

SUBMITTER: Naorem RS 

PROVIDER: S-EPMC11509883 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature