Intestinal Barrier Impairment, Preservation, and Repair: An Update.

ABSTRACT:

Background/objectives

Our objective was to review published studies of the intestinal barrier and permeability, the deleterious effects of dietary components (particularly fat), the impact of altered intestinal permeability in disease models and human diseases, the role of the microbiome and epigenomics in control of barrier function, and the opportunities to restore normal barrier function with dietary interventions and products of the microbiota.

Methods

We conducted a literature review including the following keywords alone or in combination: intestinal barrier, permeability, microbiome, epigenomics, diet, irritable bowel syndrome, inflammatory bowel disease, probiotics.

Results

Intestinal permeability is modified by a diet including fat, which increases permeabili

SUBMITTER: Matar A 

PROVIDER: S-EPMC11509958 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature