Using Hybrid MnO₂-Au Nanoflowers to Accelerate ROS Scavenging and Wound Healing in Diabetes.

ABSTRACT: Objectives: Excessive reactive oxygen species (ROS) in diabetic wounds are major contributors to chronic wounds and impaired healing, posing significant challenges in regenerative medicine. Developing innovative drug delivery systems is crucial to address these issues by modifying the adverse microenvironment and promoting effective wound healing. Methods: Herein, we designed a novel drug delivery platform using manganese dioxide nanoflower hybridized gold nanoparticle composites (MnO₂-Au) synthesized via a hydrothermal reaction, and investigated the potential of MnO₂-Au nanoflowers to relieve the high oxidative stress microenvironment and regulate diabetic wound tissue healing. Results: This hybrid material demonstrated superior catalytic activit

SUBMITTER: Jiang N 

PROVIDER: S-EPMC11509962 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature