Rutin and <i>Physalis peruviana</i> Extract: Population Pharmacokinetics in New Zealand Rabbits.

ABSTRACT: Background/Objectives: An extract of calyces from Physalis peruviana with hypoglycemic activity is being considered as a potential herbal medicine. Preclinical pharmacokinetics (PK) studies of the extract in rats, focusing on plasma concentrations of its main compound, rutin, and its metabolites, revealed PK interactions in the extract matrix that improved the absorption of rutin metabolites compared to the pure compound, among other PK effects. This research aimed to study the PK of rutin alone and in the extract and assess potential PK interactions in the extract matrix on the flavonoid and its metabolites in rabbits, a nonrodent species; Methods: Animals received pure rutin or extract orally and intravenously. The PK analysis used noncompartmental and population pha

SUBMITTER: Dominguez More GP 

PROVIDER: S-EPMC11510156 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature