Exploring Benzo[h]chromene Derivatives as Agents against Protozoal and Mycobacterial Infections.

ABSTRACT: Background/Objectives: In this study, the efficacy of benzo[h]chromene derivatives as antiprotozoal and antimycobacterial agents was explored. Methods: A total of twenty compounds, including benzo[h]chromene alkyl diesters and benzo[h]chromene-triazole derivatives, were synthesized and tested against Trypanosoma cruzi, Leishmania braziliensis, L. infantum, and strains of Mycobacterium abscessus and Mycobacterium intracellulare LIID-01. Notably, compounds 1a, 1b, 2a, and 3f exhibited superior activity against Trypanosoma cruzi, with IC₅₀ values of 19.2, 37.3, 68.7, and 24.7 µM, respectively, outperforming the reference drug benznidazole (IC₅₀: 54.7 µM). Results: Compounds 1b</

SUBMITTER: Pertino MW 

PROVIDER: S-EPMC11510191 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature