In Vitro Mucoadhesive Features of Gliadin Nanoparticles Containing Thiamine Hydrochloride.

ABSTRACT:

Background

Gliadins have aroused significant interest in the last decade as suitable biomaterials for food and pharmaceutical applications. In particular, the oral route is the preferred method of administration for gliadin-based formulations, due to the affinity of this biomaterial for the gut mucosa. However, up to now, this has been demonstrated only by means of in vivo or ex vivo studies.

Methods

This is why, in this study, various in vitro techniques were employed in order to evaluate the ability of polymeric nanoparticles, made up of a commercial grade of the protein and an etheric surfactant, to interact with porcine gastric mucin. The nanosystems were also used for the encapsulation of thiamine hydrochloride, used as a model of a micronutrient.

Results

The res

SUBMITTER: Voci S 

PROVIDER: S-EPMC11510220 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature