Froin's Syndrome: A Comprehensive Review of the Literature and the Addition of Two New Cases.

ABSTRACT:

Background

Froin's syndrome (FS) is a rare entity with uncertain prevalence and prognosis, defined by a pathognomonic triad: cerebrospinal fluid (CSF) xanthochromia, elevated protein levels in the CSF, and hypercoagulated CSF, usually obtained through lumbar puncturing below the level of a partial or complete spinal block.

Methods

We conducted a comprehensive review of the literature on FS from its first description in 1903 to December 2023, utilizing PubMed and Google Scholar, and included two new cases from our clinical practice.

Results

We describe two patients who suffered from Froin's syndrome secondary to spinal abscesses. According to our review, FS is caused by neoplasia in 33% of cases, non-malignant mechanical causes in 27%, infections in 27%, non-infectious

SUBMITTER: Jacobs L 

PROVIDER: S-EPMC11510248 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature