Association of Antibody Responses to <i>Helicobacter pylori</i> Proteins with Colorectal Adenoma and Colorectal Cancer.

ABSTRACT: Helicobacter pylori (H. pylori) has been implicated in colorectal carcinogenesis. Here, the association of immune responses to bacterial exposure with advancing stages of colorectal neoplasia was assessed by multiplex serology. Immunoglobulin (Ig) A and G antibody responses to thirteen proteins of H. pylori were measured by a Luminex-based multiplex assay in plasma from patients with colorectal cancer (CRC, n = 25), advanced adenoma (n = 82), or small polyps (n = 85) and controls (n = 100). Multivariable logistic regression was used to assess the association of bacterial seropositivity with colorectal neoplasia. The threshold for overall seropositivity required subjects to be positive for at least 4 out of the 13 tested antigens. In a cohort subset with matched data (n

SUBMITTER: Genua F 

PROVIDER: S-EPMC11510280 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature