Heterobivalent Dual-Target Peptide for Integrin-α_vβ₃ and Neuropeptide Y Receptors on Breast Tumor.

ABSTRACT: Background/Objectives: Heterodimer peptides targeting more than one receptor can be advantageous, as tumors can simultaneously express more than one receptor type. For human breast cancer, a promising biological target is tumor angiogenesis through α_vβ₃ integrin expression. Another promising target is Neuropeptide Y receptors, considering Y₁R is overexpressed in 90% of human breast tumors. This article details the development and preclinical evaluation, both in vitro and in vivo, of a novel heterodimer peptide dual-receptor-targeting probe, [^99mTc]HYNIC-cRGDfk-NPY, designed for imaging breast tumors. Methods: Female BALB/c healthy mice were used to perform biodistrubution studies and female SCID mice were subcutaneously injected wit

SUBMITTER: Ferreira AH 

PROVIDER: S-EPMC11510292 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature