SARS-CoV-2 Nucleocapsid Protein Antagonizes GADD34-Mediated Innate Immune Pathway through Atypical Foci.

ABSTRACT: The integrated stress response, especially stress granules (SGs), contributes to host immunity. Typical G3BP1⁺ stress granules (tSGs) are usually formed after virus infection to restrain viral replication and stimulate innate immunity. Recently, several SG-like foci or atypical SGs (aSGs) with proviral function have been found during viral infection. We have shown that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein induces atypical N⁺/G3BP1⁺ foci (N⁺foci), leading to the inhibition of host immunity and facilitation of viral infection. However, the precise mechanism has not been well clarified yet. In this study, we showed that the SARS-CoV-2 N (SARS2-N) protein inhibits dsRNA-induced growth arrest and DN

SUBMITTER: Liu J 

PROVIDER: S-EPMC11510332 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature