Model-Informed Precision Dosing for Personalized Ustekinumab Treatment in Plaque Psoriasis.

ABSTRACT:

Background/objectives

Implementing model-informed precision dosing (MIPD) strategies guided by population pharmacokinetic/pharmacodynamic (PK/PD) models could enhance the management of inflammatory diseases such as psoriasis. However, the extent of individual experimental data gathered during MIPD significantly influences the uncertainty in estimating individual PK/PD parameters, affecting clinical dose selection decisions.

Methods

This study proposes a methodology to individualize ustekinumab (UTK) dosing strategies for 23 Spanish patients with moderate to severe chronic plaque psoriasis., considering the uncertainty of individual parameters within a population PK/PD model.

Results

An indirect response model from previous research was used to describe the PK/PD relat

SUBMITTER: Rodriguez-Fernandez K 

PROVIDER: S-EPMC11510411 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature