Parishin A Inhibits Oral Squamous Cell Carcinoma via the AKT/mTOR Signaling Pathway.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is an aggressive cancer with limited treatment options. Parishin A, a natural compound derived from Gastrodia elata, possesses multiple therapeutic properties. However, its effects on OSCC remain unexplored.

Purpose

This study explores the anti-cancer potential of Parishin A on OSCC and its mechanisms.

Methods

OSCC cell lines YD-10B and Ca9-22 were treated with varying Parishin A concentrations. Cell viability was detected using the CCK-8 assay, and colony formation was evaluated in agarose gel. Migration and invasion ability were assessed through wound healing and Matrigel invasion assays. The protein expression levels involved in the PI3K/AKT/mTOR signaling pathway and epithelial-mesenchymal transition (EMT) mark

SUBMITTER: Ma L 

PROVIDER: S-EPMC11510427 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature