Microbiota Transplantation in Individuals with Type 2 Diabetes and a High Degree of Insulin Resistance.

ABSTRACT:

Background/objectives

The objective of this study was to determine the results of fecal microbiota transplantation (FMT) from healthy lean subjects in patients with type 2 diabetes (T2D); Methods: We designed a phase II, randomized, single-blind, parallel-arm clinical trial. Twenty-one subjects (12 men [57.1%] and 9 women [42.9%]), who had previously signed an informed consent were randomized to FMT from lean donors, a probiotic (Lactobacillus delbrueckii spp. bulgaricus LB-14), or placebo. Mean age at baseline was 62.5 ± 5.8 years and mean body mass index (BMI) at baseline was approximately 32.4 ± 2.4 kg/m². Anthropometric measures, biochemical variables, oral glucose tolerance test (OGTT), and a stool microbiota analysis were performed (baseline, 4 and 12

SUBMITTER: Gomez-Perez AM 

PROVIDER: S-EPMC11510444 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature