Analgesic and Anti-Arthritic Potential of Methanolic Extract and Palmatine Obtained from <i>Annona squamosa</i> Leaves.

ABSTRACT: Background/Objectives: Annona squamosa is used in folk medicine to treat pain and arthritis. Palmatine is an alkaloid isolated from several plants, including A. squamosa leaves. The aim of the present study was to investigate the analgesic, anti-arthritic, and anti-inflammatory potential of the methanolic extract of A. squamosa (EMAS) and palmatine. Methods: The chemical profile of EMAS was evaluated by ultra high-performance liquid chromatography with electrospray ionization coupled to mass spectrometry (UHPLC-ESI/MS). EMAS and palmatine were evaluated in carrageenan-induced pleurisy, zymosan-induced joint inflammation, formalin-induced nociception, and tumor necrosis factor (TNF)-induced mechanical hyperalgesia in experimental models in mice. A cytotoxi

SUBMITTER: Ito CNA 

PROVIDER: S-EPMC11510468 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature