From Mother to Child: Epigenetic Signatures of Hyperglycemia and Obesity during Pregnancy.

ABSTRACT:

Background

In utero exposure to maternal hyperglycemia and obesity can trigger detrimental effects in the newborn through epigenetic programming. We aimed to assess the DNA methylation levels in the promoters of MC4R and LPL genes from maternal blood, placenta, and buccal swab samples collected in children born to mothers with and without obesity and Gestational Diabetes Mellitus (GDM).

Methods

A total of 101 Caucasian mother-infant pairs were included in this study. Sociodemographic characteristics, clinical parameters, physical activity, and adherence to the Mediterranean diet were evaluated in the third trimester of pregnancy. Clinical parameters of the newborns were recorded at birth.

Results

A negative relationship between MC4R DNA methylatio

SUBMITTER: Franzago M 

PROVIDER: S-EPMC11510513 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature