Distinct Solubilization Mechanisms of Medroxyprogesterone in Gemini Surfactant Micelles: A Comparative Study with Progesterone.

ABSTRACT: The solubilization behavior of medroxyprogesterone (MP) within gemini surfactant micelles (14-6-14,2Br^-) was investigated and compared with that of progesterone to uncover distinct solubilization mechanisms. We employed ¹H-NMR and 2D ROESY spectroscopy to elucidate the spatial positioning of MP within the micelle, revealing that MP integrates more deeply into the micellar core. This behavior is linked to the unique structural features of MP, particularly its 17β-acetyl group, which promotes enhanced interactions with the hydrophobic regions of the micelle, while the 6α-methyl group interacts with the hydrophilic regions of the micelle. The 2D ROESY correlations specifically highlighted interactions between the hydrophobic chains of the surfactant and two protons of MP

SUBMITTER: Nakahara H 

PROVIDER: S-EPMC11510562 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature