Identification of the Hypoglycemic Active Components of <i>Lonicera japonica</i> Thunb. and <i>Lonicera hypoglauca</i> Miq. by UPLC-Q-TOF-MS.

ABSTRACT: Lonicera japonica Thunb. and Lonicera hypoglauca are famous Chinese medicines used for hyperglycemia; however, the specific compounds that contributed to the hypoglycemic activity and mechanism are still unknown. In this study, the antidiabetic activity of L. japonica buds and L. hypoglauca buds, roots, stems, and leaves extracts was primarily evaluated, and the L. japonica buds and L. hypoglauca buds, roots, and stems extracts displayed significant hypoglycemic activity, especially for the buds of L. hypoglauca. A total of 72 high-level compounds, including 9 iridoid glycosides, 12 flavonoids, 34 organic acids, and 17 saponins, were identified by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF

SUBMITTER: Wu Q 

PROVIDER: S-EPMC11510595 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature