Anti-Alzheimer's Potency of Rich Phenylethanoid Glycosides Extract from Marrubium vulgare L.: In Vitro and In Silico Studies.

ABSTRACT:

Background/objectives

Marrubium vulgare L. (M. vulgare), the white horehound, is well known for treating inflammation-related diseases.

Methods

In this context, we investigated the efficacy of M. vulgare ingredients in treating Alzheimer's disease using various in vitro and in silico antioxidant, anti-inflammatory, anti-cholinesterase, and anti-tyrosinase mechanisms.

Results

In our results, sixty-one components were tentatively identified using gas and liquid chromatography (GC-MS and LC-MSⁿ) and categorized as hydrocarbons, fatty acids, and polyphenolics. The extract inhibited linoleic oxidation with an IC₅₀ value of 114.72 µg/mL, captured iron (Fe²⁺) ions with an IC₅₀ value of 164.19 µg/mL, and

SUBMITTER: Emam M 

PROVIDER: S-EPMC11510615 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature