From Trypomastigotes to Trypomastigotes: Analyzing the One-Way Intracellular Journey of <i>Trypanosoma cruzi</i> by Ultrastructure Expansion Microscopy.

ABSTRACT: The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, also called American trypanosomiasis. This neglected tropical disease affects millions of individuals across the Americas. To complete its life cycle, T. cruzi parasitizes both vertebrate hosts and its vector, commonly known as the 'kissing bug'. The parasite's survival and proliferation strategies are driven by the diverse environments it encounters. Despite being described by Carlos Chagas in 1909, significant knowledge gaps persist regarding the parasite's various life forms and adaptive capabilities in response to environmental cues. In this study, we employed Ultrastructure Expansion Microscopy to explore the intricate journey of T. cruzi within the host cell. Upon entry into the ho

SUBMITTER: Tomasina R 

PROVIDER: S-EPMC11510640 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature