Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis.

ABSTRACT: Along with affecting oral health, oral microbial communities may also be endogenously translocated to the gut, thereby mediating the development of a range of malignancies in that habitat. While species-level studies have proven the capability of oral pathogens to migrate to the intestine, genetic evidence supporting this mechanism remains insufficient. In this study, we identified over 55,000 oral translocation genes (OTGs) associated with colorectal cancer (CRC) and inflammatory bowel disease (IBD). These genes are primarily involved in signal transduction and cell wall biosynthesis and show consistency in their functions between IBD and CRC. Furthermore, we found that Leclercia adecarboxylata, a newly discovered opportunistic pathogen, has a significantly high abundance in the gu

SUBMITTER: Wang L 

PROVIDER: S-EPMC11510655 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature