Effects of Free and Nanoencapsulated Benznidazole in Acute <i>Trypanosoma cruzi</i> Infection: Role of Cholinergic Pathway and Redox Status.

ABSTRACT: Background/Objectives: The Trypanosoma cruzi infection promotes an intense inflammatory process that affects several tissues. The cholinergic system may exert a regulatory immune response and control the inflammatory process. This study aimed to evaluate the comparative effect of free and nanoencapsulated benznidazole in acute T. cruzi infection to assess hematological, biochemical, and oxidative status triggered by the cholinergic system. Methods: For this, fifty female Swiss mice were distributed in eight groups, i.e., uninfected and infected animals under four treatment protocols: untreated (control-CT); vehicle treatment (Eudragit L 100-EL-100); benznidazole treatment (BNZ); and nanoencapsulated benznidazole treatment (NBNZ). After eight treatment days, the

SUBMITTER: da Silva AD 

PROVIDER: S-EPMC11510717 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature