Sodium Hypochlorite (NaClO) Disturbed Lipid Metabolism in Larval Zebrafish (<i>Danio rerio</i>), as Revealed by Lipidomics and Transcriptomics Analyses.

ABSTRACT: Sodium hypochlorite (NaClO) has been widely utilized since the initial outbreak of coronavirus disease (COVID-19). The widespread use of NaClO means that it can directly enter aquatic ecosystems through wastewater discharge. In this study, we analyzed the expression of PPAR-γ, FAS, and ACC1, which significantly increased in larval zebrafish following exposure to 300 μg/L NaClO for 7 days. Additionally, we examined the effects of high concentrations of NaClO on zebrafish through non-targeted lipidomics and transcriptomics. A total of 44 characteristic lipid molecules were identified using non-targeted lipidomics; an absolute quantitative analysis revealed that the contents of these subclasses of lipids decreased significantly following exposure to 300 μg/L NaClO for 7 d

SUBMITTER: Wang W 

PROVIDER: S-EPMC11510785 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature