Development of Smallpox Antibody Testing and Surveillance Following Smallpox Vaccination in the Republic of Korea.

ABSTRACT: Background: Despite its global eradication in 1977, smallpox remains a concern owing to its potential as a biological agent, thereby prompting the ongoing development and utilization of its vaccine. Vaccination with the Vaccinia virus induces immunity against variola virus, the causative agent of smallpox; however, this immunity does not extend to viruses of different genera within the Poxviridae family. In this study, we aimed to assess the efficacy of an enzyme-linked immunosorbent assay (ELISA) method utilizing Vaccinia virus and recombinant A27L antigen for detecting antibodies against smallpox. Methods. An analysis of the serum from 20 individuals pre- and post-vaccination with the CJ strain (CJ50300) revealed neutralizing antibodies, which were conf

SUBMITTER: Shin H 

PROVIDER: S-EPMC11510797 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature