Selenomethionine and Allicin Synergistically Mitigate Intestinal Oxidative Injury by Activating the Nrf2 Pathway.

ABSTRACT: Oxidative stress frequently contributes to intestinal barrier injury in animals and humans. It was reported that both Selenomethionine (SeMet) and allicin exhibit protective effects against a range of diseases caused by oxidative stress. This study aimed to investigate the synergistic antioxidant effects and underlying mechanisms of SeMet and allicin on a H₂O₂-induced intestinal barrier injury model using IPEC-J2 cells and mice. The results showed that H₂O₂ induced severe oxidative stress, including a decrease in cell viability, antioxidant level, migration capacity, and cell integrity. SeMet and allicin exhibited significant synergistic anti-oxidative effects on intestinal epithelial cells. The combined use of SeMet and allicin increased SOD act

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11510923 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature