A Population-Based Study of SARS-CoV-2 IgG Antibody Responses to Vaccination in Manitoba.

ABSTRACT: Understanding variables that influence antibody responses to COVID-19 vaccination within a population can provide valuable information on future vaccination strategies. In this population-based study, we examined the antibody responses to COVID-19 vaccination in Manitoba using residual serum specimens collected between January 2021 and March 2022 (n = 20,365). Samples were tested for spike and nucleocapsid IgG against SARS-CoV-2 using clinically validated assays. We assessed the impacts of multiple factors on post-vaccination antibody titres including type of vaccine, age, sex, geographic location, number of doses received, and timing of vaccination. Our investigation demonstrated that vaccination with one dose of Moderna mRNA-1273 elicited higher anti-spike IgG titres overall compared to

SUBMITTER: Martens B 

PROVIDER: S-EPMC11511381 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature