The Role of Copper in Alzheimer's Disease Etiopathogenesis: An Updated Systematic Review.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common cause of dementia and cognitive decline in the elderly. Although the etiology of AD is unknow, an increase in amyloid precursor protein (APP) leads to the toxic aggregation of Aβ plaques. Several factors, such as hypertension, diabetes, dyslipidemia, smoking, hormonal changes, and metal exposure, could increase the risk of developing AD. In this review, we will examine the role of copper (Cu) in the pathophysiology of AD, as well as the mechanisms involved in neurotoxicity and cognitive decline.

Methods

This review was conducted in accordance with PRISMA guidelines. We performed a comprehensive literature analysis over the last ten years on AD and Cu. Only late-onset Alzheimer's disease was considered; only studies on el

SUBMITTER: Sabalic A 

PROVIDER: S-EPMC11511397 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature