TLR4 as a Potential Target of Me-PFOSA-AcOH Leading to Cardiovascular Diseases: Evidence from NHANES 2013-2018 and Molecular Docking.

ABSTRACT:

Background

Concerns have been raised regarding the effects of perfluoroalkyl substance (PFAS) exposure on cardiovascular diseases (CVD), but clear evidence linking PFAS exposure to CVD is lacking, and the mechanism remains unclear.

Objectives

To study the association between PFASs and CVD in U.S. population, and to reveal the mechanism of PFASs' effects on CVD.

Methods

To assess the relationships between individual blood serum PFAS levels and the risk of total CVD or its subtypes, multivariable logistic regression analysis and partial least squares discriminant analysis (PLS-DA) were conducted on all participants or subgroups among 3391 adults from the National Health and Nutrition Examination Survey (NHANES). The SuperPred and GeneCards databases were utilized to ide

SUBMITTER: Mao Z 

PROVIDER: S-EPMC11511422 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature