Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography.

ABSTRACT:

Abstract

Epigenetics has gained considerable interest as potential mediators of molecular alterations that could underlie the prolonged sensitization of nociceptors, neurons, and glia in response to various environmental stimuli. Histone acetylation and deacetylation, key processes in modulating chromatin, influence gene expression; elevated histone acetylation enhances transcriptional activity, whereas decreased acetylation leads to DNA condensation and gene repression. Altered levels of histone deacetylase (HDAC) have been detected in various animal pain models, and HDAC inhibitors have demonstrated analgesic effects in these models, indicating HDACs' involvement in chronic pain pathways. However, animal studies have predominantly examined epigenetic modulation within the spinal

SUBMITTER: Yoo CH 

PROVIDER: S-EPMC11511648 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature