The heterogeneous wound microbiome varies with wound care pain, dressing type, and inflammatory gene expression.

ABSTRACT: Wound dressing changes are essential procedures for wound management. However, ~50% of patients experience severe pain during these procedures despite the availability of analgesic medications, indicating a need for novel therapeutics that address underlying causes of pain. Along with other clinical factors, wound pathogens and inflammatory immune responses have previously been implicated in wound pain. To test whether these factors could contribute to severe pain during wound dressing changes, we conducted an exploratory, cross-sectional analysis of patient-reported pain, inflammatory immune responses, and wound microbiome composition in 445 wounds at the time of a study dressing change. We profiled the bacterial composition of 406 wounds using 16S ribosomal RNA amplicon sequencing and qu

SUBMITTER: Campbell A 

PROVIDER: S-EPMC11511792 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature