Outer membrane protein C is a protective and unique vaccine antigen against Shigella flexneri 3a.

ABSTRACT: The anti-Shigella vaccine is one of the WHO's top priorities. Every year the disease kills more than 200,000 people worldwide and poses a serious threat to children under 5 years of age and the elderly. Increasing antibiotic resistance and limitations in diagnostics emphasize the need to develop an effective vaccine. Recent research and clinical trials report multiple approaches used in Shigella-vaccine development. However, despite the efforts of researchers, pharmaceutical companies and health care organizations, there is no licensed vaccine against shigellosis available to the community. Here, we expressed, broadly characterized and demonstrated the protective properties of outer membrane protein C as an effective molecule serving as a universal antigen for Shigella vaccine. Most of the

SUBMITTER: Jarzab A 

PROVIDER: S-EPMC11511853 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature