The Causal Effect of Adult Height on Late-Life Handgrip Strength: The Singapore Chinese Health Study.

ABSTRACT:

Background

Adult height has been associated with handgrip strength, which is a surrogate marker of physical frailty. However, it is uncertain if this association is causative or due to confounding bias.

Methods

We evaluated pairwise associations among handgrip strength, adult height, and genetically determined height (using a polygenic score [PGS] for height in a mediation framework and a 2-sample Mendelian randomization approach) by means of a multivariable regression model using a prospective cohort of Chinese living in Singapore. We additionally evaluated pathway enrichments of height-related genes in relation to increased handgrip strength to discover common biological mechanisms underlying associations of genetically determined height with handgrip strength.

Results<

SUBMITTER: Chang X 

PROVIDER: S-EPMC11511910 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature