Impact of Alcohol Consumption on Lifespan: a Mendelian randomization study in Europeans.

ABSTRACT: Alcohol is widely used but recognized as a risk factor for several adverse health outcomes based on observational studies. How alcohol affects lifespan remains controversial, with no trial to make such an assessment available or likely. We conducted a Mendelian randomization (MR) to assess the effect of alcohol on lifespan in men and women, including a possible role of smoking and education. Strong (p < 5e^- 8), independent (r² < 0.001) genetic predictors of alcohol consumption in 2,428,851 participants of European ancestry from the Sequencing Consortium of Alcohol and Nicotine use (GSCAN) consortium genome wide association study (GWAS) were applied to sex-specific GWAS of lifespan (paternal and maternal attained age) and age at recruitment to the UK Biobank. We used m

SUBMITTER: Jiesisibieke ZL 

PROVIDER: S-EPMC11511936 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature